Keyword: Healthcare-Associated Infections

ABSTRACT: Candida auris is an emerging multidrug-resistant pathogen that represents a major global health threat. It readily colonizes the skin, spreads efficiently in healthcare settings, and causes severe infections in critically ill patients. Cases of C. auris, including bloodstream infections, urinary tract infections, and co-infections with bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus, have been documented across Saudi Arabian hospitals. The pathogen has also been associated with worse outcomes in COVID-19 patients. However, data on antifungal resistance mechanisms and disease epidemiology in the Kingdom remain limited. This review synthesizes documented cases from Saudi Arabian hospitals, with a focus on clinical features, risk factors, antifungal susceptibility, and patient outcomes, to improve healthcare awareness, guide infection control strategies, and support effective management of C. aurisinfections in the region.